Functional prostaglandin E (EP) receptors in human penile corpus cavernosum
نویسندگان
چکیده
منابع مشابه
Mineralocorticoid receptor expression in human penile corpus cavernosum.
OBJECTIVES Mineralocorticoid receptor (MR) is known to play physiological and pathophysiological roles in the cardiovascular system, and MR activation directly damages these organs. The aim of this study was to evaluate the expression of MR and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in the human penile corpus cavernosum. METHODS MR and 11β-HSD2 expression was assayed in human peni...
متن کاملMultiple pathways of angiotensin I conversion and their functional role in the canine penile corpus cavernosum.
Multiple pathways of angiotensin (Ang) I conversion and their functional role in the canine penile corpus cavernosum were investigated. Biochemical analysis revealed high activities of angiotensin-converting enzyme (ACE) (6.9 +/- 1.7 mU/mg of protein, mean +/- S.E.M., n = 8) and chymase-like enzyme (4.0 +/- 1.4 mU/mg of protein). Functional recording of isometric tension showed that Ang I (3 x ...
متن کاملEffects of chronic stress on penile corpus cavernosum of rats.
The objective of this study was to investigate structural changes in the penile corpus cavernosum of prepubertal chronically stressed rats. Eight Wistar rats were assigned into the stress group (SG) and were submitted to 2 hours of tube restraint daily, from the fourth to the ninth week of life. Another 7 rats were used as the control group (CG). All animals were weighed weekly. At day 64,...
متن کاملTargeting prostaglandin E EP receptors to inhibit metastasis.
It is well established that high cyclooxygenase-2 (COX-2) expression contributes to the aggressive behavior of breast and other malignancies. Due to concerns regarding the safety of long-term use of COX-2 inhibitors as well as a desire to seek more effective alternatives to prevent and treat metastatic disease, we tested the hypothesis that inhibition of downstream signaling by the COX-2 produc...
متن کاملO2-dependent prostanoid synthesis activates functional PGE receptors on corpus cavernosum smooth muscle.
We have previously demonstrated that decreased O2 tension inhibits prostaglandin synthesis from human corpus cavernosum smooth muscle cells in static culture over 8-18 h (R. B. Moreland et al., Molecular Urology 2: 41-47, 1998). In this report, an experimental system was designed that allowed determination of the effects of O2 tension changes over the time frame of physiological penile erection...
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ژورنال
عنوان ژورنال: International Journal of Impotence Research
سال: 2003
ISSN: 0955-9930,1476-5489
DOI: 10.1038/sj.ijir.3901042